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The papers listed here are all available as open access research or are reproduced here with permission, and can be read or downloaded in full. Other papers are also available, but may require payment unless you have access via your institution. See our full list of research papers here.

  • Vasavan T, Deepak S, Jayawardane IA, Lucchini M, Martin C, Geenes V, Yang J, Lövgren-Sandblom A, Seed PT, Chambers J, Stone S, Kurlak L, Dixon PH, Marschall H-U, Gorelik J, Chappell L, Loughna P, Thornton J, Pipkin FB, Hayes-Gill B, Fifer WP, Williamson C. Fetal cardiac dysfunction in intrahepatic cholestasis of pregnancy is associated with elevated serum bile acid concentrations. J Hepatol 2020; 74(5): 1087–96.
    https://doi.org/10.1016/j.jhep.2020.11.038.
  • Ovadia C et al. Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: a systematic review and individual participant data meta-analysis. Lancet Gastroenterology & Hepatology 2021; Online 26 April.
    https://www.thelancet.com/journals/langas/article/PIIS2468-1253(21)00074-1/fulltext
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  • Mitchell A, Ovadia C, Syngelaki A, Souretis K, Martineau M, Girling J, Vasavan, T, Fan HM, Seed PT, Chambers J, Walters JRF, Nicolaides K, Williamson C. Re-evaluating diagnostic thresholds for intrahepatic cholestasis of pregnancy: case-control and cohort study. Br J Obstet Gynaecol 2021;
    https://doi.org/10.1111/1471-0528.16669
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  • Chappell LC, Bell JL, Smith A, Linsell L, Juszczak E, Dixon PH, Chambers J, Hunter R, Dorling J, Williamson C, Thornton JG. Ursodeoxycholic acid versus placebo in women with intrahepatic cholestasis of pregnancy (PITCHES): a randomised controlled trial. The Lancet 2019; 394(10201): 849–860.
    https://doi.org/10.1016/S0140-6736(19)31270-X
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  • Ovadia C, Seed PT, Sklavounos A, Geenes V, Di Illio C, Chambers J et al. Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers: results of aggregate and individual patient data meta-analyses. The Lancet 2019; 393(10174): 899–909.
    https://doi.org/10.1016/S0140-6736(18)31877-4
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  • Dixon PH, Sambrotta M, Chambers J, Taylor-Harris P, Syngelaki A, Nicolaides K, Knisely AS, Thompson RJ, Williamson, C. An expanded role for heterozygous mutations of ABCB4, ABCB11, ATP8B1, ABCC2 and TJP2 in intrahepatic cholestasis of pregnancy. Science Reports 2017; 7: 11823.
    https://doi.org/10.1038/s41598-017-11626-x
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  • Pataia V, Dixon, PH, Williamson C. Pregnancy and bile acid disorders. American Journal of Physiology – Gastrointestinal and Liver Physiology 2017; 313(1): G1–G6.
    https://doi.org/10.1152/ajpgi.00028.2017
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  • Schultz F, Hasan A, Alvarez-Laviada A, Miragoli, M, Bhogal N, Wells S, Poulet C, Chambers, J, Williamson C, Gorelik J. The protective effect of ursodeoxycholic acid in an in vitro model of the human fetal heart occurs via targeting cardiac fibroblasts. Progress in Biophysics and Molecular Biology 2016; 120(1–3): 149–163.
    http://dx.doi.org/10.1016/j.pbiomolbio.2016.01.003
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  • Abu-Hayyeh S, Ovadia C, Lieu T, Jensen DD, Chambers J, Dixon PH, Lovgren-Sandblom A, Bolier R, Tolenaars D, Kremer AE, Syngelaki A, Noori M, Williams D, Marin JJG, Monte MJ, Nicolaides KH, Beuers U, Oude-Elferink R, Seed PT, Chappell L, Marschall H-U, Bunnett NW, Williamson C. Prognostic and mechanistic potential of progesterone sulfates in intrahepatic cholestasis of pregnancy and pruritus gravidarum. Hepatology 2015; 63: 1287–1298.
    https://doi.org/10.1002/hep.28265
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  • Geenes V, Chambers J, Khurana R, Wikström Shemer E, Sia W, Mandair D, Elias E, Marschall H-U, Hague W, Williamson C. Rifampicin in the treatment of severe intrahepatic cholestasis of pregnancy. European Journal of Obstetrics & Gynecology and Reproductive Biology 2015; 189: 59&ndash63.
    https://doi.org/10.1016/j.ejogrb.2015.03.020
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  • Geenes V, Chappell LC, Seed PT, Steer PJ, Knight, M, Williamson C Association of severe intrahepatic cholestasis of pregnancy with adverse pregnancy outcomes: a prospective population-based case-control study. Hepatology 2014; 59(4): 1482–1491.
    https://doi.org/10.1002/hep.26617
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  • Chappell LC, Gurung V, Seed PT, Chambers J, Williamson C, Thornton JG. Ursodeoxycholic acid versus placebo, and early term delivery versus expectant management, in women with intrahepatic cholestasis of pregnancy: semifactorial randomised clinical trial. British Medical Journal 2012; 344: e3799.
    https://doi.org/10.1136/bmj.e3799
  • Geenes V, Williamson C. Intrahepatic cholestasis of pregnancy. World Journal of Gastroenterology 2009; 15(17): 2049–2066.
    https://dx.doi.org/10.3748/wjg.15.2049
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  • Glantz A, Marschall H-U, Mattsson L-Å. Intrahepatic cholestasis of pregnancy: Relationships between bile acid levels and fetal complication rates. Hepatology 2004; 40(2): 467–474.
    https://doi.org/10.1002/hep.20336
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  • Kremer AE, Martens JJWW, Kulik W, Ruëff F, Kuiper EMM, van Buuren HR, van Erpecum AJ, Kondrackiene J, Prieto J, Rust C, Geenes VL, Williamson C, Moolenaar WH, Beuers U, Oude Elferink RPJ. Lysophosphatidic acid is a potential mediator of cholestatic pruritus. Gastroenterology 2010; 139: 1008–1018.
    https://doi.org/10.1053/j.gastro.2010.05.009
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  • Wikström Shemer E, Marschall HU, Ludvigsson JF, Stephansson O. Intrahepatic cholestasis of pregnancy and associated adverse pregnancy and fetal outcomes: a 12-year population-based cohort study. British Journal of Obstetrics and Gynaecology 2013; 120(6): 717–723.
    https://doi.org/10.1111/1471-0528.12174
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