30 years of research – Paper No. 1
Today’s research paper was published in 1995 from researchers in Birmingham. This is the team that looked after Jenny Chambers in her last (and final) ICP pregnancy, and if you have a look at the paper you can spot that Jenny is case study 1. Although Jenny’s bile acids are plotted, at the time she was pregnant, they weren’t being measured and all the doctors had to go on were the liver function test results. It was because she donated blood to the team every week (which was then stored) that they were able to measure her bile acids two years after she had her baby. This was Jenny’s first introduction to research (she has fond memories of Dr Davies waiting to collect her placenta in theatre!), and by the time the paper was published she had become the lay representative in the research team.
Davies MH, da Silva RC, Jones SR, et al. Fetal mortality associated with cholestasis of pregnancy and the potential benefit of therapy with ursodeoxycholic acid. Gut 1995; 37: 580–584.